Table 3.
[*] IC50 values were obtained from two independent experiments.Table 3 Summary of ligand‐efficiency scores calculated on StarDrop version: 7.0.1.29911.
|
|
|
|
|
|---|---|---|---|
|
Compd |
1 |
4 |
16 |
|
PfIspD IC50 [μm] |
271±24 |
117±20 |
151±17 |
|
cLogP |
1.79 |
3.84 |
1.75 |
|
MW[a] |
262.3 |
294.1 |
270.2 |
|
HA[b] |
19 |
17 |
20 |
|
LE[c] |
0.26 |
0.32 |
0.26 |
|
LLE[d] |
1.77 |
0.085 |
2.072 |
[a] Molecular weight. [b] Non‐hydrogen atom. [c] Ligand efficiency. [d] Lipophilic ligand efficiency.