Table 2.

Dosage, administration, and treatment exposure of sapropterin dihydrochloride

	Sapropterin (N = 85)
Daily dose at treatment initiation (mg/kg)
Mean (SD)	10.352 (4.879)
Median (min, max)	9.620 (1.47, 20.06)
Dose categories, mg/kg/day, n (%)
<5	10 (11.8)
≥5–<10	41 (48.2)
≥10–<15	17 (20.0)
≥15–≤20	16 (18.8)
>20	1 (1.2)
Daily dose at the time of final observation (mg/kg)
Mean (SD)	12.036 (5.661)
Median (min, max)	10.840 (1.54, 26.67)
Dose categories, mg/kg/day, n (%)
<5	9 (10.6)
≥5–<10	26 (30.6)
≥10–<15	21 (24.7)
≥15–≤20	24 (28.2)
>20	5 (5.9)
Treatment duration (years)†
Mean (SD)	5.75 (4.47)
Median (min, max)	5.20 (0.2, 17.2)
Treatment duration categories, years, n (%)
<1	14 (16.5)
≥1–<4	24 (28.2)
≥4–<7	11 (12.9)
≥7–<10	26 (30.6)
≥10	10 (11.8)

^†Period from the start date of treatment written in the section of treatment course in the survey sheet to the end date of observation (the end date of treatment if it is written).

SD, standard deviation.