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Serum phenylalanine levels at BH4 loading tests and mean change in serum phenylalanine levels from baseline
| Test | Timing of serum measurement after loading | n | Serum phenylalanine, mg/dL | |
|---|---|---|---|---|
| Mean (SD) | Mean change (%) | |||
| BH4 single‐loading | 24 h | 65 | 8.70 (6.98) | –32.37 |
| BH4 4‐times loading | 4 or 8 h | 17 | 5.54 (1.83) | –20.43 |
| 24 h | 18 | 5.43 (2.39) | –22.01 | |
| 52 h | 18 | 4.93 (3.10) | –32.03 | |
| BH4 1‐week loading | 4 days | 47 | 5.70 (5.08) | –45.86 |
| 7 days | 48 | 6.09 (5.54) | –41.85 | |
BH4, tetrahydrobiopterin; SD, standard deviation.
