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. 2022 Jul 13;18(12):4781–4791. doi: 10.7150/ijbs.72109

Figure 1.

Figure 1

Humoral immune responses in hamsters vaccinated with inactivated viruses. (A) Schematic diagram showing the procedure for generation of the inactivated vaccine in this study. (B) Abbreviations used for the indicated inactivated vaccine groups. (C) Vaccination scheme. Hamsters were intramuscularly injected with various inactivated SARS-CoV-2 strains or placebo control (PBS) at days 0 and 14. Blood samples were collected at days 0, 14, 21 and 28 for ELISA or neutralization tests. (D-H) Neutralization activity of serum samples collected at day 28 post-vaccination from hamsters immunized with different inactivated vaccines. The neutralization activity of the serum samples collected at day 28 post-vaccination were analyzed by sVNT or microneutralization assay with the indicated VOCs of SARS-CoV-2. (D) cPass SARS-CoV-2 neutralization antibody detection. The broken line indicates detection limit. (E-H) Microneutralization assay with sera from the indicated groups collected at day 28 post-vaccination against WT (E) and the following three VOCs of SARS-CoV-2: Omicron/B.1.1.529 (F), Delta/B.1.617.2 (G) and Alpha/B.1.1.7 (H).