Table 1.
Effect of Adipokines on PC.
| Adipokines | Receptor | Expression | Link | Effect | Signaling | References |
|---|---|---|---|---|---|---|
| Leptin | LEPR | ↑ | ↑ | Proliferation (+) Migration (+) Invasion (+) Durg resistance (+) |
JAK2/STAT3, PI3K/AKT Notch |
(21, 22) (23–25) |
| Adiponectin | AdipoR1 AdipoR2 | ↓ (large-scale) ↑ (small-scale) |
↓ | Proliferation (−) Migration (–) Invasion (–) Pro-apoptotic (+) |
Caspase β-Catenin |
(26–31) |
| Resistin | TLR4 CAP1 |
↑ | ↑ | Proliferation (+) Migration (+) Invasion (+) Durg resistance (+) Pro-inflammatory (+) |
STAT3 | (32) |
| Oncostatin | gp130/LIFRβ gp130/OSMRβ |
↑ | ↑ | Proliferation (+) Migration (+) Invasion (+) Durg resistance (+) Pro-inflammatory (+) TME reprogramming (+) |
JAK/STAT3 ERK2/Sp1 |
(33–37) |
| Osteopontin | OPN- integrin- CD44 |
↑ | ↑ | Proliferation (+) Migration (+) Invasion (+) TME reprogramming (+)Immune escape (+) |
Akt/Erk FOXM1/ H3K4me3 |
(38–41) (42–45) |
| Kisspeptin | KISS-1R (Gpr54) | ↓ (Tissue) ↑ (Serum) |
↑ | Proliferation (–) Migration (+) Invasion (+) |
ERK1/p38 | (46–50) |
| Omentin | Unknown | ↑ | ↑ | Unknown | Unknown | (51, 52) (53, 54) |
| Chemerin | Chemerin 1 Chemerin 2 CCRL2 | ↑ | ↑ | Unknown | Unknown | (53) |
ANNOTATION : ↑ mean promote, ↓ mean suppress; The link column refers to the impact on PC development; (+) mean exist (–), mean absent; The Effect column refers to the specific outcome of adipokines to PC.