Table 2.
Characteristics of the INQ substrates
| Features/p-valuesa | INQ versus whole proteome | INQ versus nuclear proteome | References |
|---|---|---|---|
| Length | 0.259 | 0.575 | - |
| Hydropathy score (GRAVY) | 0.182 | 0.147 | (84) |
| Aliphatic index | 0.065 | 0.645 | (85) |
| Charged amino acids % | 0.052 | 0.702 | - |
| Abundance (ppm) | 0.963 | 0.629 | (86) |
| Solubility score | 0.174 | 0.251 | (87) |
| Disorder % | 0.267 | 0.473 | (88) |
| LCR (low complexity regions)% | 0.095 | 0.040 | (89) |
| Pi-pi interaction score (phase separation propensity) | 0.262 | 0.694 | (90) |
a
Proteomic features were assessed using in-house R scripts, packages, and softwares cited in the table. The exact p-values resulting from a Mann–Whitney–Wilcoxon test after Bonferroni correction for multiple comparisons are reported (values in bold represent p-value <0.05)