Table 3.

Main results of the meta-analysis of HLA-G 14bp I/D polymorphism with digestive cancers.

Cancer type	Ethnicity	Genetic model	N	Odds ratio			Heterogeneity			PEgger	PBegg
				OR	95% CI	POR	I2(%)	Tau2	PH
DC	Overall	D vs. I	10	1.127	0.918–1.383	0.254	73.86	0.075	0.000	0.998	0.858
		DD + ID vs. II		1,115	0.813–1.530	0.500	58.18	0.136	0.011	0.983	0.721
		DD vs DI + II		1,215	0.939–1.,572	0,138	66.62	0.105	0.001	0.764	0.858
	Asian	D vs. I	4	1.040	0.724–1.495	0.832	81.3	0.109	0.001	0.255	0.497
		DD + ID vs. II		1.083	0.524–2.239	0.830	73.3	0.379	0.010	0.404	1
		DD vs DI + II		1.162	0.956–1.411	0.131	71.6	0.112	0.014	0.293	0.042
CRC	Overall	D vs. I	3	1,015	0.698–1.477	0.937	81.58	0.089	0.004	0.934	1
		DD + ID vs. II		0,891	0.607–1.308	0.555	53.56	0.061	0.116	0.635	1
		DD vs DI + II		1,179	0.641–2.167	0.597	83.52	0.238	0.002	0.693	1
EC	Asian	D vs. I	2	1.107	0.8820–1.389	0.382	88	0.198	0.004	NA	NA
		DD + ID vs. II		1.179	0.735–1.890	0.495	85.5	0.682	0.009	NA	NA
		DD vs DI + II		1.121	0.806–1.558	0.497	80.4	0.236	0.024	NA	NA
HCC	Overall	D vs. I	4	1.152	0.827–1.605	0.404	66.2	0.071	0.031	0.571	0.174
		DD + ID vs. II	4	1.291	0.753–2.211	0.353	37.2	0.109	0.189	0.109	0.042
		DD vs DI + II	4	1.213	0.836–1.760	0.310	54.3	0.072	0.087	0.860	0.174
	Asian	D vs. I	2	1.164	0.956–1.418	0.131	86.9	0.202	0.006	NA	NA
		DD + ID vs. II		1.349	0.805–2.263	0.256	76.4	1.050	0.040	NA	NA
		DD vs DI + II		1.184	0.931–1.506	0.169	81.5	0.186	0.020	NA	NA

bp: base pairs, CI: Confidence interval, CRC: Colorectal cancer, DC: Digestive cancers, EC: Esophageal cancer, HCC: Hepatocellular cancer, I/D: insertion/deletion, N: number of studies, NA: Not applicable, OR: odds ratio, P_Begg: P-value associated to Begg and Mazumdar rank correlation test (Two-tailed) without continuity correction, P_Egger: P-value associated to Egger’s test (Two-tailed), P_H: P-value associated to heterogeneity, P_OR: P-value associated to OR, Bold: significant P-value (≤0.05).