Table 5.
Meta-analysis results of sHLA-G significance in digestive cancers initiation∗.
| Ethnicity | Fluidics | Cancer type | Effects Models | N | Standardized mean differences |
Heterogeneity |
PEgger | PBegg | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SMD | SEM | 95% CI | PSMD | I2(%) | Tau2 | PH | |||||||
| Overall | All | DC | R | 16 | 3.341 | 0.472 | 2.415–4.267 | 0.000 | 98 | 3.392 | 0.000 | 0.011 | 0.015 |
| CRC | R | 5 | 2.165 | 0.847 | 0.506–3.824 | 0.011 | 97.9 | 3.473 | 0.000 | 0.686 | 0.327 | ||
| GC | R | 5 | 4.043 | 0.926 | 2.28–5.858 | 0.000 | 98.46 | 4.011 | 0.000 | 0.142 | 0.142 | ||
| Serum/Plasma | DC | R | 11 | 3.994 | 0.613 | 2.793–5.195 | 0.000 | 98.6 | 3.952 | 0.000 | 0.004 | 0.016 | |
| CRC | R | 3 | 2.686 | 1.289 | 0.159–5.214 | 0.037 | 98.9 | 4.923 | 0.000 | 0.636 | 0.602 | ||
| Caucasian | All | DC | F | 4 | 0.831 | 0.143 | 0.551–1.111 | 0.000 | 98.3 | 6.448 | 0.000 | 0.113 | 0.042 |
| Serum/Plasma | GC | F | 2 | 0.905 | 0.186 | 0.541–1.269 | 0.000 | 99.4 | 119.190 | 0.000 | NA | NA | |
| Asian | All | DC | F | 12 | 2.292 | 0.072 | 2.150–4.434 | 0.000 | 97.6 | 2.849 | 0.000 | 0.034 | 0.11 |
| Ascite | DC | F | 3 | 1.666 | 0.257 | 1.163–2.169 | 0.000 | 48.7 | 0.193 | 0.143 | 0.083 | 0.117 | |
| Serum/Plasma | CRC | F | 2 | 2.266 | 0.127 | 2.016–2.516 | 0.000 | 99.3 | 9.349 | 0.000 | NA | NA | |
| EC | F | 2 | 2.625 | 0.190 | 2.253–2.997 | 0.000 | 98.8 | 6.328 | 0.000 | NA | NA | ||
| GC | F | 2 | 1.818 | 0.122 | 1.579–2.058 | 0.000 | 98.5 | 2.861 | 0.000 | NA | NA | ||
| HCC | F | 3 | 4.058 | 0.230 | 3.608–4.508 | 0.000 | 97.3 | 6.115 | 0.000 | 0.217 | 0.217 | ||
CI: Confidence interval, CRC: Colorectal cancer; DC: digestive cancer; EC: Esophageal cancer; F:Fixed effects model, GC: Gastric cancer; HCC: Hepatocellular cancer; N: number of studies, NA: Not applicable, PBegg: P-value associated to Begg and Mazumdar rank correlation test (Two-tailed) without continuity correction, PEgger: P-value associated to Egger’s test (Two-tailed), PH: P-value associated to heterogeneity, PSMD: P-value associated to SMD, R: Random effects model, SEM: Standard errors of the mean, SMD: standardized mean differences, Bold: significant P-value (≤0.05). ∗ Cases vs. healthy controls.