Skip to main content
. 2022 Feb 27;55(12):1545–1559. doi: 10.1111/apt.16850

FIGURE 6.

FIGURE 6

Follow‐up of an eAg(−) chronic hepatitis B cohort after NUC therapy discontinuation according to the probability of the presence of a functional HBV‐specific CD8+ cell response at the time of treatment withdrawal. (A) Dynamics of patient outcomes during off‐treatment follow‐up according to the probability level of detecting a functional HBV‐specific CD8+ cell response at the time of treatment discontinuation, calculated using the predictive model developed in the study. (B) Kaplan–Meier curves showing the frequency of eAg(−) chronic hepatitis B cases with HBsAg loss and > 50% HBsAg decline with respect to baseline without need for retreatment, according to the level of probability of detecting peripheral functional HBV‐specific CD8+ cells at discontinuation of treatment, based on the predictive model developed in the study. N, number of cases exposed during the different periods; M, month; Prob, probability. §HBV control comprises an inactive carrier and grey‐zone status. †Chi‐square test. ‡Log‐rank test (Mantel‐Cox)