Figure 8.

Comparison of binding poses of TC and DsbA inhibitors. A. Structure overlay of benzimidazole 2 (cyan sticks) with the VcDsbA (white surface, blue sticks)‐TC (yellow stick) complex. B. Structural overlay of the complexes of diaryl ether 3 (cyan sticks) with the EcDsbA (white surface, blue sticks)‐TC (yellow) complex (PDB ID: 6PDH). In both cases the active site Cys30 and Cys33 residues are shown as orange sticks, sulfur atoms shown as yellow spheres. Residues within 6 Å of TC are shown as blue sticks and interacting waters as red spheres with key residues labelled. Polar contacts are shown as dashed black lines. C. Chemical structure of diaryl ether 3.