TABLE 1.
Demographics and baseline characteristics of subjects with RA in the exposure‐response analysis dataset
| Subject characteristic | DARWIN 1 (n = 520) | DARWIN 2 (n = 257) | FINCH 1 (n = 926) | FINCH 2 (n = 290) | FINCH 3 (n = 796) | |
|---|---|---|---|---|---|---|
| Continuous variables, median (min, max) | ||||||
| Age (y) | 55 (19, 79) | 52 (18, 79) | 53 (18, 86) | 56 (20, 80) | 53 (18,85) | |
| Body weight (kg) | 72.3 (39, 157) | 72.0 (37, 181) | 68.3 (35.6, 143) | 78.4 (40.6, 157) | 71.0 (36.3, 148) | |
| CLcr (mL/min) | 110 (38.0, 312) | 115 (54.6, 264) | 107 (38.0, 291) | 113 (49.2, 298) | 109 (36.6, 311) | |
| CRP (mg/L) | 16.7 (1, 158) | 17.1 (1, 244) | 8.88 (0.19, 163) | 10.7 (0.34, 145) | 0.81 (0.02, 18.8) | |
| RA duration (y) | 6.2 (0.5, 43.2) | 6.9 (0.5, 49.6) | 5.3 (0.1, 45.4) | 10.1 (0.9, 49.7) | 0.4 (0.0, 47.6) | |
| Categorical variables, n (%) | ||||||
| Sex | Male | 99 (19.0%) | 48 (18.7%) | 174 (18.8%) | 59 (20.4%) | 175 (22.0%) |
| Female | 421 (81.0%) | 209 (81.3%) | 751 (81.2%) | 230 (79.6%) | 620 (78.8%) | |
| Race N (%) | White | 394 (75.8%) | 193 (75.1%) | 617 (66.7%) | 211 (73.0%) | 515 (64.8%) |
| Black | 3 (0.6%) | 3 (1.2%) | 14 (1.5%) | 26 (9.0%) | 31 (3.9%) | |
| Asian | 2 (0.4%) | 1 (0.4%) | 232 (25.1%) | 35 (12.1%) | 182 (22.9%) | |
| Other | 121 (23.3%) | 60 (23.3%) | 62 (6.7%) | 17 (5.9%) | 67 (8.4%) | |
Abbreviations: CLcr, creatinine clearance; CRP, C‐reactive protein; max, maximum; min, minimum; N, number of subjects; RA, rheumatoid arthritis.