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An overview of the crosstalk of molecular pathways with cytoskeletal agents, mechanosensors and external forces. Some of these relationships present exciting new targets for cancer research and therapy and need to be explored more fully in osteosarcoma cells in the context of mechanotransduction. ECM, extracellular matrix; FA, focal adhesions; ONM/INM, outer nuclear membrane/inner nuclear membrane; AC + RELA, acetylated RELA
