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. 2022 Jan 12;28(8):e202103995. doi: 10.1002/chem.202103995

Figure 2.

Figure 2

(A) Activity of Renilla luciferase‐targeting siRNA‐M2 constructs on a Renilla luciferase reporter in 293T cells. (B) Activity of Renilla luciferase‐targeting siRNA‐M2 constructs on the same reporter in Dicer‐deficient (NoDice) cells. [23] (C) Activity of control siRNA‐M2 constructs on a Renilla luciferase reporter in 293T cells. (D) Activity of control siRNA‐M2 constructs on the same reporter in NoDice cells. [23] In (A–D), siREN and siRND served as positive and negative controls. Treatments were transfected at 0, 2.5, 10, and 40 nM. Data are mean Renilla/Firefly values normalized to the 0 nM treatment ±SD (n=3). Statistics are two‐way ANOVA with Dunnett's multiple comparisons test against the 0 nM treatment: *P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001.