Table 2.
Dysregulated Ang2 in cancer.
| Cancer type | Regulatory factors | Effects on the expression of Ang2 | Cancer Development | References |
|---|---|---|---|---|
| Gastric cancer | miRNA-542-3p | ↓ | Inhibit cancer cell proliferation, migration | (37) |
| miR-218 | ↓ | Inhibit cancer cell proliferation and invasion | (39) | |
| miR-145-5p | ↓ | Inhibit cancer cell proliferation, migration and invasion | (40) | |
| LINC00184 | ↑ | Induced EMT characteristics of gastric cancer cells | (41) | |
| DARPP-32 | ↑ | Promotes cancer cell proliferation, invasion and migration | (42) | |
| Lung cancer | ADAM9 | ↑ | Promotes cancer cell migration | (54) |
| Glioma | BMAL1 | ↑ | Promotes cancer cell proliferation, invasion and migration | (55) |
| ISL2 | ↑ | Promotes cancer cell proliferation, invasion and migration | (13) | |
| Colorectal cancer | RAS-ERK1/2 | ↑ | Promotes cancer cell migration | (67) |
| Breast cancer | Estrogen | ↓ | Inhibit cancer cell proliferation | (72) |
| Pancreatic cancer | miR-145 | ↓ | Inhibit cancer cell proliferation and invasion | (74) |
| Cerebral cavernous malformation (CCM) | CCM3 | ↓ | Inhibit cancer cell proliferation, migration and invasion | (75) |
| Kaposi’s sarcoma | Kaposi sarcoma-associated herpesvirus (KSHV) | ↑ | Promotes cancer cell proliferation, invasion and migration | (77) |
| Osteosarcoma | Connective tissue growth factor (CTGF) | ↑ | Promotes cancer cell migration | (79) |
| Melanoma | TS | ↓ | Inhibit tumor angiogenesis | (80) |