Table 1.

Nurr1 agonism of the purified compounds 3 j, 4, 4 e, and 5. AQ (1), ^[29] CQ, ^[29] 2 ^[24] and lead fragment 3 ^[24] for comparison. Fold activation refers to the maximum Nurr1 activation vs. DMSO (0.1 %). Data are the mean±S.E.M., n≥3.

ID	structure	EC50(Nurr1) (fold act.)
AQ		36±4 μM (3.6±0.1‐fold)
CQ		47±5 μM (2.0±0.1‐fold)
2		1.8±0.3 μM (1.47±0.03‐fold)
3		259±70 μM (2.5±0.4‐fold)
3 j		8±1 μM (2.5±0.1‐fold)
4		3.0±0.1 μM (2.0±0.1‐fold)
4 e		6±2 μM (1.40±0.05‐fold)
5		47±13 μM (2.0±0.2‐fold)