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. 2022 Jul 8;12:915957. doi: 10.3389/fonc.2022.915957

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Copyright © 2022 Lv, Xu, Yuan, Wang and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The function of Par3 in tumor promotion. The activation of Rac1 is mediated by Par3/aPKCλ, which is necessary to promote the activation of Stat3. Par3 interacts with PP1A and the Hippo pathway kinase Lats1 to induce its dephosphorylation and thereby lead to the activation of TAZ in the cytoplasm. Par3 also sequesters Kibra to form a Par3/aPKC/Kibra complex, leading to the dissociation of the canonical Kibra/Merlin/FRMD6 complex and a decrease in the phosphorylation of Lats, resulting in the dephosphorylation of Yap for cytoplasmic arrest.