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. 2022 Mar 31;101(9):1110–1118. doi: 10.1177/00220345221084975

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Figure 5. — Exosome treatment ameliorated periodontal bone loss in vivo. (A) Experiment timeline. Ligatures were placed around the left maxillary second molar (M2) for 3 wk. Exosomes or saline were injected to gingival tissues once a week. (B) Representative micro–computed tomography images of the ligated and nonligated maxillae. (C) Normalized bone volume/tissue volume (BV/TV) representing the ratio between treatment (left side) versus healthy control (right side). (D) Normalized linear alveolar bone loss (ABL) representing the ratio of treatment (left side)/healthy control (right side). (E) Hematoxylin and eosin staining. Upper panels, low magnification (the scale bars were 200 µm). Lower panels, high magnification of the areas in the yellow boxes (the scale bars were 50 µm). (F) Quantitative measurement of infiltrated lymphocytes in the interproximal gingival tissues.