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. 2022 Jul 21;21:150. doi: 10.1186/s12943-022-01605-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Down-regulation of lncRNA MARCKSL1–2 is associated with DTX resistance and poor prognosis in LAD patients. a MARCKSL1–2 expression was detected by RT-qPCR in the DTX sensitive- (CR + PR; n = 28) and insensitive- (SD + PD; n = 32) LAD tissues. b MARCKSL1–2 expression in normal lung tissues (n = 20) and LAD tissues (n = 60) was determined by RT-qPCR. c Kaplan-Meier analysis of the association between progression-free survival (PFS) and MARCKSL1–2 level in LAD patients. d Kaplan-Meier analysis of the association between overall survival (OS) and MARCKSL1–2 level in LAD patients. e RT-qPCR tested the expression of MARCKSL1–2 in DTX-resistant LAD cells relative to parental H1299 or SPC-A1 cells. f-g Subcellular fractionation analyzed MARCKSL1–2 distribution in LAD cells and matched DTX-resistant cells. h IF analysis of MARCKSL1–2 distribution in parental and DTX-resistant LAD cells. Scale bar = 20 μm. ^**P < 0.01