Table 1.
Receiver-operating characteristics analyses of the different thromboelastometric tests
| Detection Level | ROTEM Variable | AUC | SE | P-Value | Sensitivity | Specificity | Optimum cut-off |
|---|---|---|---|---|---|---|---|
| Apixaban > 30 ng/mL | TFTEM CT | 0.9530 | 0.02285 | < 0.0001 | 88 | 95 | > 179 |
| Apixaban > 30 ng/mL | ECATEM CT | 0.6425 | 0.05871 | 0.0207 | 48 | 85 | < 92 |
| Apixaban > 30 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9455 | 0.02458 | < 0.0001 | 84 | 95 | > 1.988 |
| Apixaban > 30 ng/mL | EXTEM CT | 0.8965 | 0.03687 | < 0.001 | 70 | 95 | > 68 |
| Apixaban > 30 ng/mL | FIBTEM CT | 0.7935 | 0.04646 | < 0.0001 | 68 | 78 | > 66 |
| Apixaban > 30 ng/mL | HEPTEM CT | 0.7740 | 0.06150 | 0.0004 | 76 | 75 | > 195 |
| Apixaban > 30 ng/mL | NATEM CT | 0.6000 | 0.06037 | 0.1044 | 80 | 40 | > 779 |
| Apixaban > 60 ng/mL | TFTEM CT | 0.9605 | 0.02503 | < 0.0001 | 93 | 94 | > 210 |
| Apixaban > 60 ng/mL | ECATEM CT | 0.6343 | 0.05876 | 0.0292 | 55 | 72 | < 95 |
| Apixaban > 60 ng/mL | EXTEM CT | 0.9236 | 0.03171 | < 0.0001 | 83 | 90 | > 68 |
| Apixaban > 60 ng/mL | FIBTEM CT | 0.8588 | 0.04026 | < 0.0001 | 80 | 78 | > 66 |
| Apixaban > 60 ng/mL | HEPTEM CT | 0.7975 | 0.05315 | < 0.0001 | 67 | 49 | > 195 |
| Apixaban > 60 ng/mL | NATEM CT | 0.6458 | 0.05851 | 0.0179 | 65 | 60 | > 858 |
| Apixaban > 60 ng/ml | TFTEM/ ECATEM CT-ratio | 0.9570 | 0.02555 | < 0.0001 | 85 | 98 | > 2.460 |
| Edoxaban > 30 ng/mL | TFTEM CT | 0.9975 | 0.002884 | < 0.0001 | 100 | 98 | > 199 |
| Edoxaban > 30 ng/mL | ECATEM CT | 0.6520 | 0.05802 | 0.0136 | 52 | 70 | < 96 |
| Edoxaban > 30 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9985 | 0.001759 | < 0.0001 | 96 | 100 | > 2.244 |
| Edoxaban > 30 ng/mL | EXTEM CT | 0.9990 | 0.001691 | < 0.0001 | 98 | 100 | > 73 |
| Edoxaban > 30 ng/mL | FIBTEM CT | 0.9738 | 0.01303 | < 0.0001 | 94 | 90 | > 72 |
| Edoxaban > 30 ng/mL | HEPTEM CT | 0.9455 | 0.02461 | < 0.0001 | 82 | 95 | > 213 |
| Edoxaban > 30 ng/mL | NATEM CT | 0.6525 | 0.05782 | 0.0133 | 46 | 90 | > 1041 |
| Edoxaban > 60 ng/mL | TFTEM CT | 0.9870 | 0.007937 | < 0.0001 | 98 | 92 | > 264 |
| Edoxaban > 60 ng/mL | ECATEM CT | 0.5710 | 0.06042 | 0.2489 | 80 | 34 | < 101 |
| Edoxaban > 60 ng/mL | EXTEM CT | 0.9896 | 0.008586 | < 0.0001 | 95 | 100 | > 84 |
| Edoxaban > 60 ng/mL | FIBTEM CT | 0.9905 | 0.007477 | < 0.0001 | 95 | 98 | > 81 |
| Edoxaban > 60 ng/mL | HEPTEM CT | 0.9358 | 0.02911 | < 0.0001 | 85 | 97 | > 222 |
| Edoxaban > 60 ng/mL | NATEM CT | 0.7330 | 0.05592 | 0.0002 | 55 | 90 | > 1041 |
| Edoxaban > 60 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9765 | 0.01263 | < 0.0001 | 98 | 90 | > 2.719 |
| Rivaroxaban > 30 ng/mL | TFTEM CT | 0.9980 | 0.002176 | < 0.0001 | 98 | 98 | > 198 |
| Rivaroxaban > 30 ng/mL | ECATEM CT | 0.6585 | 0.05850 | 0.0101 | 62 | 73 | < 103 |
| Rivaroxaban > 30 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9975 | 0.002879 | < 0.0001 | 98 | 100 | > 2.180 |
| Rivaroxaban > 30 ng/mL | FIBTEM CT | 0.9985 | 0.001892 | < 0.0001 | 98 | 100 | > 86 |
| Rivaroxaban > 30 ng/mL | NATEM CT | 0.8125 | 0.04512 | < 0.0001 | 84 | 68 | > 896 |
| Rivaroxaban > 60 ng/mL | TFTEM CT | 0.9850 | 0.008727 | < 0.0001 | 93 | 96 | > 304 |
| Rivaroxaban > 60 ng/mL | ECATEM CT | 0.7060 | 0.05722 | 0.0008 | 73 | 70 | > 101 |
| Rivaroxaban > 60 ng/mL | FIBTEM CT | 0.9890 | 0.007630 | < 0.0001 | 93 | 98 | > 106 |
| Rivaroxaban > 60 ng/mL | NATEM CT | 0.8425 | 0.04153 | < 0.0001 | 78 | 80 | > 953 |
| Rivaroxaban > 60 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9770 | 0.01268 | < 0.0001 | 98 | 90 | > 2.568 |
| Any DXaI > 30 ng/mL | TFTEM CT | 0.9828 | 0.008352 | < 0.0001 | 96 | 95 | > 179 |
| Any DXaI > 30 ng/mL | ECATEM CT | 0.5453 | 0.04771 | 0.3788 | 39 | 78 | < 95 |
| Any DXaI > 30 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9805 | 0.008711 | < 0.0001 | 90 | 100 | > 2.180 |
| Any DXaI > 30 ng/mL | FIBTEM CT | 0.9219 | 0.01925 | < 0.0001 | 81 | 90 | > 72 |
| Any DXaI > 30 ng/mL | NATEM CT | 0.6883 | 0.04377 | 0.0003 | 52 | 80 | > 948 |
| Any DXaI > 60 ng/mL | TFTEM CT | 0.9494 | 0.01469 | < 0.0001 | 89 | 86 | > 264 |
| Any DXaI > 60 ng/mL | ECATEM CT | 0.5214 | 0.04320 | 0.6235 | 25 | 84 | > 107 |
| Any DXaI > 60 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9387 | 0.01728 | < 0.0001 | 90 | 86 | > 2.719 |
| Any DXaI > 60 ng/mL | FIBTEM CT | 0.8971 | 0.02208 | < 0.0001 | 81 | 86 | > 79 |
| Any DXaI > 60 ng/mL | NATEM CT | 0.7362 | 0.03582 | < 0.0001 | 61 | 81 | > 948 |
| Dabigatran > 30 ng/mL | TFTEM CT | 0.9460 | 0.02185 | < 0.0001 | 96 | 83 | > 150 |
| Dabigatran > 30 ng/mL | ECATEM CT | 1.0 | 0.0 | < 0.0001 | 100 | 100 | > 128 |
| Dabigatran > 30 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9190 | 0.02917 | < 0.0001 | 78 | 100 | < 0.9251 |
| Dabigatran > 30 ng/mL | FIBTEM CT | 0.9975 | 0.002520 | < 0.0001 | 98 | 98 | > 78 |
| Dabigatran > 30 ng/mL | NATEM CT | 0.9820 | 0.01001 | < 0.0001 | 96 | 90 | > 1049 |
| Dabigatran > 60 ng/mL | TFTEM CT | 0.9578 | 0.01826 | < 0.0001 | 95 | 84 | > 164 |
| Dabigatran > 60 ng/mL | ECATEM CT | 1.0 | 0.0 | < 0.0001 | 100 | 100 | > 177 |
| Dabigatran > 60 ng/mL | FIBTEM CT | 0.9823 | 0.01004 | < 0.0001 | 95 | 92 | > 97 |
| Dabigatran > 60 ng/mL | NATEM CT | 0.9760 | 0.01212 | < 0.0001 | 93 | 90 | > 1182 |
| Dabigatran > 60 ng/mL | TFTEM/ ECATEM CT-ratio | 0.9420 | 0.02975 | < 0.0001 | 88 | 100 | < 0.8779 |
| Any DOAC > 30 ng/mL | TFTEM CT | 0.9736 | 0.009820 | < 0.001 | 90 | 95 | > 179 |
| Any DOAC > 30 ng/mL | ECATEM CT | 0.5910 | 0.03951 | 0.0693 | 26 | 100 | > 123 |
| Any DOAC > 30 ng/mL | FIBTEM CT | 0.9408 | 0.01481 | < 0.0001 | 80 | 98 | > 78 |
| Any DOAC > 30 ng/mL | NATEM CT | 0.7618 | 0.03522 | < 0.0001 | 55 | 90 | > 1041 |
| Any DOAC > 30 ng/ml | TFTEM/ECATEM ratio | 0.7556 | 0.02939 | < 0.0001 | 68 | 100 | > 2.180 |
| Any DOAC > 60 ng/mL | TFTEM CT | 0.9200 | 0.01693 | < 0.0001 | 88 | 78 | > 219 |
| Any DOAC > 60 ng/mL | ECATEM CT | 0.5921 | 0.03689 | 0.0200 | 25 | 100 | > 177 |
| Any DOAC > 60 ng/mL | FIBTEM CT | 0.8958 | 0.01974 | < 0.0001 | 86 | 78 | > 79 |
| Any DOAC > 60 ng/mL | NATEM CT | 0.7563 | 0.03090 | < 0.0001 | 62 | 81 | > 1041 |
| Any DOAC > 60 ng/ml | TFTEM/ECATEM ratio | 0.7186 | 0.03370 | < 0.0001 | 68 | 88 | > 2.719 |
AUC Area under the curve, SE Standard error, CT Clotting time, DOAC Direct oral anticoagulant