Table 2.
Demographic characteristics and laboratory findings of pyogenic liver abscess patients with sepsis or prolonged hospital stays
| Sepsis | Prolonged hospital stays | |||||
|---|---|---|---|---|---|---|
| Sepsis (n = 80) | Non-sepsis (n = 292) | p value | > 21d (n = 61) | ≤ 21d (n = 311) | p value | |
| Age (years) | 63.5 ± 13.6 | 61.4 ± 13.4 | 0.210 | 65.8 ± 13.8 | 61.0 ± 13.3 | 0.011 |
| Gender (male), n (%) | 50(62.5) | 165(56.5) | 0.336 | 30(49.2) | 127(40.8) | 0.228 |
| BMI | 24(22–26) | 23.5(22–26) | 0.115 | 23.5(21.3–25.5) | 24(22–26) | 0.717 |
| Comorbidities | ||||||
| Hypertension | 31(38.8) | 104(35.6) | 0.606 | 30(49.2) | 105(33.8) | 0.022 |
| Diabetes mellitus | 39(48.8) | 116(39.7) | 0.147 | 33(54.1) | 122(39.2) | 0.031 |
| Fatty liver | 16(20.0) | 24(8.2) | 0.003 | 12(19.7) | 28(9.0) | 0.014 |
| Cholelithiasis | 16(20.0) | 76(26.0) | 0.268 | 16(26.2) | 76(24.4) | 0.767 |
| Viral hepatitis | 9(11.2) | 48(16.4) | 0.254 | 8(13.1) | 49(15.8) | 0.601 |
| Chronic renal insufficiency | 20(25.0) | 7(2.4) | < 0.001 | 12(19.7) | 15(4.8) | < 0.001 |
| Malignancy | 5(6.2) | 9(3.1) | 0.187 | 3(4.9) | 11(3.5) | 0.604 |
| Cardiovascular diseases | 16(20.0) | 54(18.5) | 0.760 | 18(29.5) | 52(16.7) | 0.019 |
| Hepatic dysfunction | 30(37.5) | 40(13.7) | < 0.001 | 19(31.1) | 51(16.4) | 0.007 |
| Gastrointestinal surgery history | 8(10.0) | 38(13.0) | 0.468 | 6(9.8) | 40(12.9) | 0.512 |
| Microbiological etiology | 0.022 | 0.173 | ||||
| Klebsiella pneumoniae | 39(48.8) | 106(36.3) | 30(49.2) | 115(37.0) | ||
| Escherichia coli | 18(22.5) | 52(17.8) | 11(18.0) | 59(19.0) | ||
| Others | 23(28.8) | 134(45.9) | 20(32.8) | 137(44.1) | ||
| Abscess size(cm) | 0.994 | 0.025 | ||||
| < 5 | 21(26.2) | 75(25.7) | 11(18.0) | 85(27.3) | ||
| 5–10 | 54(67.5) | 199(68.2) | 42(68.9) | 211(67.8) | ||
| > 10 | 5(6.2) | 18(6.2) | 8(13.1) | 15(4.8) | ||
| Abscess number | 0.914 | 0.612 | ||||
| Single lesion | 64(80.0) | 232(79.5) | 50(82.0) | 246(79.1) | ||
| Multiple lesions | 16(20.0) | 60(20.5) | 11(18.0) | 65(20.9) | ||
| Treatment | 0.168 | 0.060 | ||||
| Antibiotics alone | 14(17.5) | 78(26.7) | 8(13.1) | 84(27.0) | ||
| Antibiotics + Percutaneous drainage | 62(77.5) | 206(70,5) | 50(82.0) | 218(70.1) | ||
| Antibiotics + Surgical drainage | 4(5.0) | 8(2.7) | 3(4.9) | 9(2.9) | ||
| Complications | ||||||
| Acute respiratory distress syndrome | 6(7.5) | 2(0.7) | 0.000 | 5(8.2) | 3(1.0) | 0.004 |
| Peritoneal effusion | 11(13.8) | 22(7.5) | 0.083 | 8(13.1) | 25(8.0) | 0.202 |
| Spontaneous rupture of abscess | 4(5.0) | 1(0.3) | 0.008 | 3(4.9) | 2(0.6) | 0.033 |
| Extrahepatic manifestations | 16(20.0) | 4(1.4) | 0.000 | 10(16.4) | 10(3.2) | 0.000 |
| ICU admission | 22(27.5) | 7(2.4) | 0.000 | 14(23.0) | 15(4.8) | 0.000 |
| Laboratory findings | ||||||
| WBC (109/L) | 12.5(10.6–16.8) | 11.2(8.8–15.2) | 0.013 | 12.5(10.5–16.6) | 11.3(8.9–15.2) | 0.047 |
| Hb (g/L) | 120.0(108.0–133.8) | 118.5(105.0–129.0) | 0.316 | 120(101.5–128) | 119(106–130.5) | 0.459 |
| PLT (109/L) | 98.0(66.0–167.5) | 221.5(151.5–332.8) | < 0.001 | 135(79.5–225) | 210(136–318) | < 0.001 |
| Neu (109/L) | 11.1(9.2–15.1) | 9.1(6.9–12.6) | < 0.001 | 10.7(9.0–14.5) | 9.4(7.0–12.9) | 0.007 |
| Ly (109/L) | 0.6(0.5–1.0) | 1.2(0.7–1.6) | < 0.001 | 0.7(0.5–1.3) | 1.1(0.7–1.5) | 0.003 |
| NLR | 19.2(10.4–26.5) | 8.3(5.1–14.7) | < 0.001 | 15.3(8.8–21.5) | 9.3(5.2–15.9) | < 0.001 |
| BUN (mmol/L) | 8.2(5.2–12.4) | 4.6(3.6–6.0) | < 0.001 | 6.9(4.2–10.2) | 4.8(3.7–6.5) | < 0.001 |
| Cr (μmol/L) | 78.0(63.5–110.3) | 63.0(53.0–78.0) | < 0.001 | 76(51–100.5) | 66(54–78.5) | 0.050 |
| ALT (U/L) | 71.0(43.5–115.5) | 45.0(26.0–77.0) | < 0.001 | 56(35.5–104.5) | 48(27–82.5) | 0.148 |
| ALP (U/L) | 152.5(104.0–234.0) | 166.0(117.8–229.8) | 0.219 | 174(105.5–222.5) | 162(116–233.5) | 0.779 |
| TBIL (μmol/L) | 19.7(13.0–37.4) | 14.0(9.4–21.1) | < 0.001 | 16.7(10.6–29.1) | 14.3(9.8–23.9) | 0.145 |
| TBA (μmol/L) | 8.2(4.3–20.0) | 5.2(2.9–9.9) | < 0.001 | 9.4(5–15.5) | 5.3(2.8–10.1) | 0.002 |
| ALB (g/L) | 28.5 ± 5.6 | 31.6 ± 5.6 | < 0.001 | 28.8 ± 4.7 | 31.4 ± 5.8 | < 0.001 |
| CRP (mg/L) | 188(140.9–266.1) | 114(50.1–173) | < 0.001 | 176.7(141.2–239.9) | 120(50.1–183.0) | < 0.001 |
| FIB (g/L) | 6.7(5.7–7.8) | 6.4(5.6–7.6) | 0.302 | 6.9(6.0–7.9) | 6.4(5.6–7.6) | 0.044 |
| CPR | 1.8(1.0–3.6) | 0.5(0.2–1.0) | < 0.001 | 1.5(0.9–3.0) | 0.5(0.3–1.2) | < 0.001 |
| NLPR | 16.8(8.6–33.2) | 3.6(1.6–9.7) | < 0.001 | 13.4(5.2–26.6) | 4.6(1.8–12.0) | < 0.001 |
| FPR | 6.01(3.8–11.4) | 2.8(1.9–4.2) | < 0.001 | 5.1(2.8–10.1) | 3.0(2.0–4.8) | < 0.001 |
Bold type indicates statistical significance (p < 0.05)
WBC white blood cells, Hb hemoglobin, PLT platelets, Neu neutrophils, Ly lymphocytes, NLR neutrophil to lymphocyte, BUN blood urea nitrogen, Cr creatinine, ALT alanine transaminase, ALP alkaline phosphatase, TBIL total bilirubin, TBA total bile acid, ALB albumin, CRP C-reactive protein, FIB fibrinogen, CPR C-reactive protein-to-platelet ratio, NLPR neutrophil-to-lymphocyte*platelet ratio, FPR fibrinogen-to-platelet ratio