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. 2022 Jul 22;22:273. doi: 10.1186/s12883-022-02801-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Patients of the two cohorts divided by their NPis and NPi differentials. < NPi = 0 > are patients that had at least one occurrence of a non-responsive pupil. < low NPi high diff > are patients that had at least one abnormal NPi (NPi < 3) and at least one NPi differential (abs[NPi(left) – NPi(right)] ≥ 0.7); finally, < normal > , are patients with all normal NPi’s and no NPi differentials. The group with < NPi = 0 > was associated with the most severe mRS. The two groups with one or both abnormalities were all significantly better than < NPi = 0 > (asterisks indicates P < .001) but all equally poorer than the group with normal NPi’s and no NPi differentials. Error bars are 95% Cis