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. 2022 Jul 21;41:228. doi: 10.1186/s13046-022-02438-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effects of C1GALT1 on malignant behavior of BLCA cells. A C1GALT1 expression in C1GALT1-silenced YTS-1 cells (termed shC#1–3) with/without Doxy treatment. B-D Proliferation of C1GALT1-silenced YTS-1 vs. control cells by CCK8 (B) and Edu assay (C, D). ***, p < 0.001. E, F Migratory ability (E) and colony formation (F) of C1GALT1-silenced YTS-1 vs. control cells. ***, p < 0.001. G-I Tumor size (G), weight (H), and volume (I) for mice injected with C1GALT1-silenced, ITZ-treated, and control YTS-1 cells (n = 7). *, p < 0.05; **, p < 0.01; ***, p < 0.001. J-L Tumor size (J), weight (K) and volume (L) for PDXs with/without ITZ treatment. M, N Microphotographs of splenic (M) and liver metastatic tumors (N). O A popliteal lymphatic metastasis model was established by inoculating the foot pads of nude mice with YTS-1 cells. P, Q Size of LNs (P) and metastasis ratios (Q) of popliteal lymphatic metastasis mouse model