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. 2022 Jul 21;41:228. doi: 10.1186/s13046-022-02438-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of miR-1-3p on malignant behavior of BLCA cells. A Correlation analysis of miR-1-3p and C1GALT1 mRNA expression in BLCA patients, from TCGA database. B Confirmation of miR-1-3p-binding sites on 3′-UTR of C1GALT1 detected by luciferase reporter assay. Control miRNA or miR-1-3p mimics were co-transfected with luciferase reporters containing wild-type or mutated 3′-UTRs. **, p < 0.01. C, D miR-1-3p (C), C1GALT1 expression, and T antigen levels (D) in miR-1-3p-overexpressing YTS-1 cells with Doxy treatment. *, p < 0.05. E-G Proliferation (E), migratory ability (F), and colony formation (G) of miR-1-3p-overexpressing YTS-1 vs. control cells. ***, p < 0.001. H-J Tumor size (H), volume (I), and weight (J) at wk. 3 after s.c. injection of miR-1-3p-overexpressing YTS-1 cells (n = 7). *, p < 0.05; **, p < 0.01. K, L Microphotographs of splenic (K) and liver metastatic tumors (L)