Table 2.
Unadjusted and adjusted odds ratio (OR) analysis for the significantly altered metabolites associated with high-risk CVD, low-risk CVD, and diabetes mellitus
| Metabolites | Diabetes/ controls | Diabetes + low risk CVD/ controls | ||||||
| OR (95% CI) | P-Value | P-Valuea | P-Valueb | OR (95% CI) | P-Value | P-Valuea | P-Valueb | |
| Serine | 1.021 (1.003–1.039) | 0.025 | 0.026 | 0.000 | 1.026 (1.006–1.045) | 0.009 | 0.009 | 0.000 |
| C10:1 | 1.003 (0.999–1.007) | 0.134 | 0.166 | 0.899 | 1.006 (1.001–1.01) | 0.016 | 0.017 | 0.579 |
| C14:1 | 0.979 (0.964–0.994) | 0.007 | 0.006 | 0.000 | 0.989 (0.974–1.004) | 0.147 | 0.151 | 0.000 |
| C14:2 | 0.974 (0.958–0.991) | 0.003 | 0.003 | 0.000 | 0.974 (0.955–0.993) | 0.007 | 0.008 | 0.000 |
| C16:1 | 0.940 (0.906–0.975) | 0.001 | 0.001 | 0.859 | 0.969 (0.942–0.997) | 0.031 | 0.041 | 0.999 |
| C18 | 1.027 (1.003–1.051) | 0.030 | 0.038 | 0.865 | 1.042 (1.011–1.074) | 0.007 | 0.009 | 0.689 |
| C18:1 | 0.986 (0.974–0.997) | 0.017 | 0.011 | 0.788 | 0.994 (0.984–1.005) | 0.271 | 0.478 | 0.988 |
| C18:2OH | 0.994 (0.989–0.998) | 0.006 | 0.008 | 0.546 | 0.995 (0.99–0.999) | 0.020 | 0.020 | 0.625 |
| Metabolites | Diabetes + high risk CVD/ controls | Diabetes + high risk CVD/ diabetes | ||||||
| OR (95% CI) | P-Value | P-Valuea | P-Valueb | OR (95% CI) | P-Value | P-Valuea | P-Valueb | |
| Serine | 1.023 (1.005–1.041) | 0.010 | 0.008 | 0.000 | 1.002 (0.989–1.015) | 0.732 | 0.630 | 0.341 |
| C10:1 | 1.004 (1.001–1.08) | 0.037 | 0.027 | 0.879 | 1.001 (0.997–1.005) | 0.579 | 0.372 | 0.578 |
| C14:1 | 0.983 (0.97–0.997) | 0.016 | 0.010 | 0.000 | 1.005 (0.99–1.019) | 0.534 | 0.631 | 0.072 |
| C14:2 | 0.980 (0.965–0.994) | 0.006 | 0.005 | 0.000 | 1.005 (0.99–1.021) | 0.509 | 0.610 | 0.532 |
| C16:1 | 0.976 (0.956–0.997) | 0.023 | 0.025 | 0.742 | 1.039 (1.003–1.076) | 0.034 | 0.028 | 0.036 |
| C18 | 1.032 (1.008–1.056) | 0.008 | 0.009 | 0.988 | 1.005 (0.982–1.029) | 0.683 | 0.560 | 0.830 |
| C18:1 | 0.989 (0.979–0.999) | 0.027 | 0.060 | 0.854 | 1.003 (0.991–1.016) | 0.590 | 0.311 | 0.060 |
| C18:2OH | 0.998 (0.996–1.0) | 0.083 | 0.081 | 0.889 | 1.005 (1.0–1.009) | 0.043 | 0.072 | 0.122 |
Results were shown as odds ratio (OR) and the corresponding 95% confidence intervals (CI)
a Adjusted P-Value by age, BMI, and time of menopause
b Adjusted P-Value by age, BMI, time of menopause, lipid profile, diabetes duration, and medications
C10:1, Decenoylcarnitine; C14:1, Tetradecenoylcarnitine; C14:2, Tetradecadienoylcarnitine; C16:1, Hexadecenoylcarnitine; C18, Octadecanoylcarnitine; C18:1, Octadecenoylcarnitine; C18:2-OH, 3-OH-octadecadienoyl