Table 1.

miRNAs involved in senescence or OA

miRNAs	Mainly target molecule or pathways	Effects	References
miR-290		Promotes senescence in mouse embryo fibroblasts	Pitto et al. (2009) [146]
miR-22	CDK6, SIRT1, Sp1 mRNA	Induces cellular senescence and suppresses tumour	Xu et al. (2011) [147]
miR-302, miR-512-3p miR-515-3p	p21 mRNA	Rescue Ras(G12V)-induced senescence	Borgdorff et al. (2010) [148]
miR-302b	IRAK4 mRNA	Inhibits NF-κB pathways	Afonina et al. (2017) [141]
miR-146a	TRAF6 mRNA	Inhibits NF-κB pathways	O'Connell et al. (2012) [142]
miR-34a	SIRT1 mRNA	Inhibits chondrocyte proliferation, promotes senescence and apoptosis	Yan et al. (2016) [145]
miR-204		Inhibits proteoglycan (PG) biosynthesis	Kang et al. (2019) [144]
miR-140	IGF1R and TLR4 in PI3K-AKT pathway and JAG1 and NUMBL in the Notch pathway	Inhibits chondrocyte senescence and attenuates early OA development	Si et al. (2020) [143]
miR-126, miR-130a, miR-142, miR-21, miR-93		Are associated with ageing	Olivieri et al. (2017) [149]