Table 1.
Baseline characteristics of study participants.
| Fertility-sparing (n = 23) | Poor surgical fitness (n = 48) | All participants (n = 71) | |
|---|---|---|---|
| Demographics | |||
| Median age (IQR), years | 31 (28–35) | 62 (58–68) | 58 (35–65) |
| White British, n (%) | 18 (78) | 47 (98) | 65 (92) |
| Asian, n (%) | 5 (22) | 0 (0) | 5 (7) |
| Black, n (%) | 0 (0) | 1 (2) | 1 (1) |
| Mean weight (SD), kg | 119 (24.11) | 129 (23.13) | 126 (23.81) |
| Mean BMI (SD), kg/m2 | 43 (7.30) | 50 (9.29) | 48 (9.34) |
| Menopausal status, n (%) | |||
| Premenopausal | 23 (100) | 4 (8) | 27 (38) |
| Postmenopausal | 0 (0) | 44 (92) | 44 (62) |
| Median parity (IQR) | 0 (0–0) | 2 (1–3) | 1 (0–2) |
| Medical status | |||
| PCOS, n (%) | 16 (70) | 0 (0) | 16 (23) |
| T2DM, n (%) | 3 (13) | 19 (40) | 22 (31) |
| Mean HbA1C (range), mmol/mol | 38 (25–61) | 45 (29–102) | 43 (25–102) |
| Mean Fasting glucose (range), mmol/L | 5.8 (4.0–9.9) | 6.6 (4.3–15.5) | 6.3 (4.0–15.5) |
| Hypertension, n (%) | 1 (4) | 39 (81) | 40 (56) |
| Hypercholesterolemia, n (%) | 0 (0) | 20 (42) | 20 (28) |
| Smoker, n (%) | 3 (13) | 5 (10) | 8 (11) |
| Cardiovascular disease, n (%) | 0 (0) | 12 (25) | 12 (17) |
| Mean CRP (range), mg/L | 8.7 (1–20) | 12.0 (1–52) | 10.9 (1–52) |
| Pathologic findings | |||
| Atypical hyperplasia, n (%) | 8 (35) | 23 (48) | 31 (44) |
| Endometrioid adenocarcinoma, n (%) | 15 (65) | 25 (52) | 40 (56) |
| Grade 1, n (%) | 15 (100) | 24 (96) | 39 (98) |
| Grade 2, n (%) | 0 (0) | 1 (4) | 1 (2) |
| Radiologic findings | |||
| Median endometrial thickness (IQR), mm | 12 (9–15) | 8 (5–12) | 10 (6–14) |
| Endometrial mass lesion, n (%) | 3 (13) | 5 (10) | 8 (11) |
| Myometrial invasion, n (%) | 1 (4) | 5 (10) | 6 (8) |
| Benign adnexal mass, n (%) | 3 (13) | 4 (8) | 7 (10) |
Abbreviations: PCOS, Polycystic ovary syndrome; T2DM, Type 2 diabetes mellitus.