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. 2021 Jun 4;30(8):1591–1598. doi: 10.1158/1055-9965.EPI-20-1765

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©2021 The Authors; Published by the American Association for Cancer Research

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Figure 4. The PUFA metabolic pathways and other biological routes to carcinogenesis. Schematic diagram showing downstream metabolism of essential fatty acids LA and ALA into proinflammatory and anti-inflammatory eicosanoids and free radicals, such as ROS. LOX, lipoxygenase; COX, cyclooxygenases (COX-1 and COX-2); PGE, prostaglandin E; ROS, reactive oxygen species; FADS2, fatty acid desaturase 2; FADS1, fatty acid desaturase 1. — The PUFA metabolic pathways and other biological routes to carcinogenesis. Schematic diagram showing downstream metabolism of essential fatty acids LA and ALA into proinflammatory and anti-inflammatory eicosanoids and free radicals, such as ROS. LOX, lipoxygenase; COX, cyclooxygenases (COX-1 and COX-2); PGE, prostaglandin E; ROS, reactive oxygen species; FADS2, fatty acid desaturase 2; FADS1, fatty acid desaturase 1.