Figure 4.
The PUFA metabolic pathways and other biological routes to carcinogenesis. Schematic diagram showing downstream metabolism of essential fatty acids LA and ALA into proinflammatory and anti-inflammatory eicosanoids and free radicals, such as ROS. LOX, lipoxygenase; COX, cyclooxygenases (COX-1 and COX-2); PGE, prostaglandin E; ROS, reactive oxygen species; FADS2, fatty acid desaturase 2; FADS1, fatty acid desaturase 1.