Table 1.

The instrument variables for the PUFAs that were used for the MR study.

PUFA	CHR	Gene	SNP	A1*	A2	A1 Freq	P	Beta	SE	VE per allele (%)
Linoleic acid (LA)	10	NRBF2	rs10740118	G	C	0.56	8.1 × 10–09	0.248	0.043	0.2–0.7
	11	FADS1	rs174547	C	T	0.32	5.0 × 10–274	1.474	0.042	7.6–18.1
	16	NTAN1	rs16966952	A	G	0.31	1.2 × 10–15	0.351	0.044	0.5–2.5
Arachidonic acid (AA)	11	FADS1	rs174547	T	C	0.68	3.3 × 10–971	1.691	0.025	3.7–37.6
	16	NTAN1	rs16966952	G	A	0.69	2.4 × 10–10	0.199	0.031	0.1–0.6
Alpha-linolenic acid (ALA)	11	FADS1	rs174547	C	T	0.33	4.0 × 10–64	0.016	0.001	1.03
Eicosapentaenoic acid (EPA)	6	ELOVL2	rs3798713	C	G	0.43	2.0 × 10–12	0.035	0.005	0.36
	11	FADS1	rs174538	G	A	0.72	5.0 × 10–58	0.083	0.005	1.69
Docosapentaenoic acid (DPA)	6	ELOVL2	rs3734398	C	T	0.43	1.0 × 10–43	0.04	0.003	0.46
	11	FADS1	rs174547	T	C	0.67	4.0 × 10–154	0.075	0.003	2.74
	2	GCKR	rs780094	T	C	0.41	9.0 × 10–09	0.017	0.003	8.38
Docosahexaenoic acid (DHA)	6		rs2236212	G	C	0.57	1.3 × 10–15	0.113	0.014	0.65
A1*-PUFA increasing allele		A2 - other allele				SE - standard error
VE- variance explained		IV - instrument variable				A1 Freq - frequency of PUFA increasing allele