Figure 2.

Electron tomography structure of the NPC from different angles. The orange/yellow-labeled proteins form a ring-shaped structure that anchors the NPC to the nuclear envelope of the thickness of ~40 nm and that serves as the scaffold for the attachment of intrinsically disordered polypeptides, here schematically depicted in green. The purple structure is the nuclear basket. While the structure of the scaffold is now known to a high precision, the distribution of the intrinsically disordered domains in the passageway is much less defined. The diameter of the internal passageway is approximately 35-59 nm, and the overall length is ~100 nm, (including the basket). Note that the cytoplasmic filaments are not well resolved. Adapted from [7] and [8], permission pending.