Figure 25.

The ratio of the predicted steady-state flux of a transport protein (illustrated as blue arrow) to that of a non-binding protein of the same size (illustrated as orange arrow). The effective diffusion coefficient in the bound state inside the channel decreases with the binding affinity of the transport protein to the FG nups/polymers, resulting in a non-monotonic dependence of the flux through the NPC-like channel on the interaction strength. See text. Adapted from [268], permission pending.