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. 2022 Mar 3;82(5):749–763. doi: 10.1158/0008-5472.CAN-21-2930

Figure 1.

Figure 1. Current treatment algorithm in myelofibrosis based on risk stratification according to the mutation enhanced international prognostic scoring system (MIPSS70+ version 2.0). Genetic risk factors: very high-risk karyotype, 4 points; unfavorable karyotype, 3 points; ≥2 high risk mutations, 3 points; one high risk mutation, 2 points; type 1 CALR absent, 2 points. Clinical risk factors: constitutional symptoms, 2 points; severe anemia, 2 points; moderate anemia, 1 point; ≥2% circulating blasts, 1 point.

Current treatment algorithm in myelofibrosis based on risk stratification according to the mutation enhanced international prognostic scoring system (MIPSS70+ version 2.0). Genetic risk factors: very high-risk karyotype, 4 points; unfavorable karyotype, 3 points; ≥2 high risk mutations, 3 points; one high risk mutation, 2 points; type 1 CALR absent, 2 points. Clinical risk factors: constitutional symptoms, 2 points; severe anemia, 2 points; moderate anemia, 1 point; ≥2% circulating blasts, 1 point.