Table 3.

Regression Models of the Relationships Between the Interaction of IL-6 and Neighborhood Crime Rates on NAc and OFC Activation

Dependent Variable	Model 1				Model 2				Model 3
	B	SE	t	p	B	SE	t	p	B	SE	t	p
NAc: Receipt of Social Acceptance
Constant	−0.271	0.254	−1.066	.291	−0.197	0.247	−0.799	.428	−0.194	0.250	−0.776	.441
BMI	0.005	0.021	0.241	.810	0.007	0.020	0.346	.730	0.006	0.021	0.283	.778
Sex	−0.368	0.307	1.201	.235	0.325	0.296	1.098	.277	0.322	0.299	1.079	.285
Med	0.107	0.356	0.299	.766	0.081	0.343	0.234	.816	0.078	0.347	0.224	.824
Illness	0.271	0.451	0.602	.550	0.399	0.438	0.911	.367	0.394	0.442	0.892	.376
Dep Hx	0.020	0.318	0.064	.949	0.055	0.308	−0.178	.859	−0.059	0.311	−0.190	.850
SES	–	–	–	–	–	–	–	–	−0.033	0.156	−0.208	.836
IL-6	−0.046	0.542	−0.085	.932	−0.072	0.522	−0.137	.891	−0.057	0.531	−0.107	.915
Crime	<0.001	<0.001	−0.181	.857	<−0.001	<0.001	0.484	.630	<0.001	<0.001	0.454	.652
IL-6 × crime	–	–	–	–	0.001	<0.001	2.342	.023a	0.001	<0.001	2.329	.023a,b
ΔR2	–	–	–	–	0.084	–	–	–	0.085	–	–	–
R2	0.043	–	–	–	0.127	–	–	–	0.128	–	–	–
NAc: Monetary Reward Anticipation
Constant	0.148	0.117	1.263	.212	0.139	0.119	1.172	.246	0.148	0.119	1.242	.219
BMI	−0.009	0.010	−0.897	.373	−0.009	0.010	−0.919	.362	−0.011	0.010	−1.139	.259
Sex	−0.220	0.140	−1.569	.122	−0.213	0.141	−1.507	.137	−0.218	0.141	−1.540	.129
Med	0.335	0.164	2.043	.046a	0.338	0.165	2.047	.045a	0.330	0.165	2.001	.050
Illness	−0.117	0.208	−0.561	.577	−0.133	0.211	−0.633	.529	−0.143	0.211	−0.681	.499
Dep Hx	−0.226	0.146	−1.545	.128	−0.217	0.148	−1.469	.147	−0.228	0.148	−1.537	.130
SES	–	–	–	–	–	–	–	–	−0.075	0.074	−1.017	.314
IL-6	0.236	0.249	0.949	.346	0.238	0.250	0.950	.346	0.270	0.252	1.071	.289
Crime	<0.001	<0.001	−0.507	.614	<−0.001	<0.001	−0.676	.502	<0.001	<0.001	−0.801	.426
IL-6 × crime	–	–	–	–	<−0.001	<0.001	−0.615	.541	<−0.001	<0.001	−0.564	.575
ΔR2	–	–	–	–	0.005	–	–	–	0.005	–	–	–
R2	0.160	–	–	–	0.165	–	–	–	0.180	–	–	–
NAc: Monetary Reward Outcome
Constant	−0.148	0.175	−0.846	.401	−0.122	0.175	−0.694	.491	−0.114	0.177	−0.646	.521
BMI	−0.004	0.014	−0.289	.773	−0.003	0.014	−0.235	.815	−0.006	0.015	−0.372	.711
Sex	0.065	0.209	0.312	.756	0.045	0.209	0.216	.830	0.041	0.210	0.195	.846
Med	0.707	0.244	2.895	.005c	0.700	0.244	2.874	.006c	0.693	0.245	2.829	.006c
Illness	0.125	0.309	0.403	.688	0.174	0.311	0.559	.578	0.165	0.313	0.527	.600
Dep Hx	−0.160	0.218	−0.733	.466	−0.186	0.218	−0.853	.397	−0.195	0.220	−0.888	.378
SES	–	–	–	–	–	–	–	–	−0.066	0.110	−0.598	.552
IL-6	0.144	0.371	0.389	.699	0.140	0.369	0.379	.706	0.168	0.374	0.449	.655
Crime	<−0.001	<0.001	−1.049	.298	<−0.001	<0.001	−0.602	.549	<−0.001	<0.001	−0.671	.505
IL-6 × crime	–	–	–	–	<0.001	<0.001	1.221	.227	<0.001	<0.001	1.243	.219
ΔR2	–	–	–	–	0.021	–	–	–	0.022	–	–	–
R2	0.162	–	–	–	0.183	–	–	–	0.188	–	–	–
OFC: Receipt of Social Acceptance
Constant	−0.039	0.245	−0.158	.875	1.316	0.243	0.054	.957	0.024	0.245	0.100	.921
BMI	−0.025	0.020	−1.222	.227	−0.023	0.020	−1.171	.247	−0.027	0.021	−1.295	.201
Sex	0.288	0.295	0.977	.333	0.258	0.291	0.885	.380	0.249	0.293	0.853	.398
Med	0.398	0.342	1.161	.250	0.379	0.337	1.125	.265	0.370	0.339	1.091	.280
Illness	−0.719	0.434	−1.658	.103	−0.629	0.430	−1.462	.149	−0.642	0.433	−1.485	.143
Dep Hx	0.343	0.305	−1.123	.266	0.396	0.302	−1.309	.196	−0.410	0.305	−1.345	.184
SES	–	–	–	–	–	–	–	–	−0.104	0.153	−0.679	.500
IL-6	0.331	0.521	0.636	.527	0.313	0.513	0.611	.544	0.360	0.520	0.692	.492
Crime	<−0.001	<0.001	−0.264	.793	<0.001	<0.001	0.219	.827	<0.001	<0.001	0.142	.887
IL-6 × crime	–	–	–	–	<0.001	<0.001	1.677	.099	0.001	<0.001	1.695	.096
ΔR2	–	–	–	–	0.041	–	–	–	0.042	–	–	–
R2	0.133	–	–	–	0.173	–	–	–	0.180	–	–	–
OFC: Monetary Reward Anticipation
Constant	0.139	0.082	1.688	.097	0.132	0.083	1.579	.120	0.139	0.083	1.669	.101
BMI	0.004	0.007	0.632	.530	0.004	0.007	0.596	.554	0.002	0.007	0.284	.778
Sex	−0.119	0.099	−1.207	.232	−0.114	0.099	−1.142	.258	−0.117	0.099	−1.186	.241
Med	0.135	0.115	1.168	.247	0.137	0.116	1.182	.242	0.131	0.116	1.132	.262
Illness	−0.129	0.146	−0.884	.380	−0.143	0.148	−0.968	.337	−0.152	0.148	−1.029	.308
Dep Hx	−0.243	0.103	−2.354	.022a	−0.235	0.104	−2.261	.028a	−0.244	0.104	−2.350	.022a
SES	–	–	–	–	–	–	–	–	−0.063	0.052	−1.221	.227
IL-6	−0.146	0.175	−0.833	.408	−0.145	0.176	−0.823	.414	−0.117	0.176	−0.665	.508
Crime	<0.001	<0.001	0.013	.990	<−0.001	<0.001	−0.225	.823	<−0.001	<0.001	−0.381	.704
IL-6 × crime	–	–	–	–	<−0.001	<0.001	−0.734	.466	<−0.001	<0.001	−0.676	.502
ΔR2	–	–	–	–	0.008	–	–	–	0.007	–	–	–
R2	0.155	–	–	–	0.163	–	–	–	0.184	–	–	–
OFC: Monetary Reward Outcome
Constant	0.096	0.101	0.944	.349	0.072	0.100	0.721	.474	0.080	0.100	0.799	.428
BMI	−0.005	0.008	−0.596	.553	−0.006	0.008	−0.697	.488	−0.008	0.008	−0.943	.350
Sex	−0.198	0.121	−1.635	.107	−0.180	0.119	−1.516	.135	−0.184	0.119	−1.553	.126
Med	0.293	0.142	2.066	.043a	0.300	0.139	2.165	.035a	0.293	0.139	2.118	.039a
Illness	−0.007	0.180	−0.039	.969	−0.051	0.177	−0.291	.772	−0.061	0.177	−0.343	.733
Dep Hx	−0.116	0.127	−0.914	.364	−0.091	0.124	−0.739	.463	−0.101	0.124	−0.814	.419
SES	–	–	–	–	–	–	–	–	−0.068	0.062	−1.091	.280
IL-6	−0.063	0.215	−0.294	.770	−0.059	0.210	−0.283	.779	−0.030	0.212	−0.143	.887
Crime	<−0.001	<0.001	−0.629	.532	<−0.001	<0.001	−1.240	.220	<0.001	<0.001	−1.372	.175
IL-6 × crime	–	–	–	–	<−0.001	<0.001	−1.951	.056	<0.001	<0.001	−1.898	.063
ΔR2	–	–	–	–	0.053	–	–	–	0.050	–	–	–
R2	0.136	–	–	–	0.189	–	–	–	0.206	–	–	–

The three sets of models present regression models without the interaction term (model 1), with the interaction term (model 2), and with the inclusion of neighborhood SES (model 3). R² is the value for the regression model, and ΔR² is the change when the IL-6 × crime interaction term is added to the model.

BMI, body mass index; Dep Hx, depression history; FDR, false discovery rate; IL-6, interleukin 6; Med, medication; NAc, nucleus accumbens; OFC, orbitofrontal cortex; SES, socioeconomic status.

^ap < .05.

^bUncorrected p values remained significant after controlling the FDR of 5%.

^cp < .01.