TABLE 2.

THR-184 overview.

A novel therapeutic that activates the BMP pathway and minimizes AKI

Peptide mimetic of the active portion of BMP-7

Binds BMP type I receptors ALK2 and ALK3, but not ALK6

Prevents apoptosis, cytokine release and fibrosis

Does not induce bone growth

Does not promote cancer growth

Does not inhibit wound healing

Does not affect bleeding time

Does not affect hemodynamics

Has no off-target interactions (114 targets surveyed)

Has no effect on key CYP450 isoforms (1A2, 2C19, 2C9, 2D6, 3A4)