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. 2022 Feb 3;20(2):183–192. doi: 10.1158/1541-7786.MCR-21-0282

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©2021 The Authors; Published by the American Association for Cancer Research

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Figure 1. Overview of the TME. In the bulk tumor, cancer cells interact with a complex meshwork of ECM proteins, including collagen and fibronectin. Cancer cells also interact with a milieu of stromal cells, including endothelial cells, pericytes, immune cells, and CAFs. As the tumor develops, cancer cells communicate with the TME through cytokines, growth factors, and extracellular vesicles. — Overview of the TME. In the bulk tumor, cancer cells interact with a complex meshwork of ECM proteins, including collagen and fibronectin. Cancer cells also interact with a milieu of stromal cells, including endothelial cells, pericytes, immune cells, and CAFs. As the tumor develops, cancer cells communicate with the TME through cytokines, growth factors, and extracellular vesicles.