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. 2022 Feb 3;20(2):183–192. doi: 10.1158/1541-7786.MCR-21-0282

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©2021 The Authors; Published by the American Association for Cancer Research

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Figure 4. Model for the evolution of CAFs with tumor progression. CAFs are heterogenous and dynamic in nature. Tumor progression could be associated with a decrease of the tumor-inhibitory CAF/tumor-supporting CAF ratio, with highest levels seen at earlier tumor stages as a reaction to tumor emergence followed by a progressive conversion towards a tumor-supporting CAF that overtakes the CAF compartment. — Model for the evolution of CAFs with tumor progression. CAFs are heterogenous and dynamic in nature. Tumor progression could be associated with a decrease of the tumor-inhibitory CAF/tumor-supporting CAF ratio, with highest levels seen at earlier tumor stages as a reaction to tumor emergence followed by a progressive conversion towards a tumor-supporting CAF that overtakes the CAF compartment.