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A novel pathway patched together from promiscuous enzyme activities restores synthesis of PLP in ΔpdxB E. coli by bypassing the block in the pathway. Promiscuous enzymes that normally serve other functions are highlighted in red. SerA, 3-phosphoglycerate dehydrogenase; SerC, phosphoserine/phosphohydroxythreonine aminotransferase; ThrB, homoserine kinase.
