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. 2022 Feb 3;20(4):845–856. doi: 10.1111/jth.15653

TABLE 5.

Linear regression analysis of MEA and TGA assays: unstandardized coefficients

Multiple electrode aggregometry Thrombin generation assays
ASPI test ADP test TRAP test Lag Time ETP Time to peak Peak thrombin
Age −0.16 0.12 0.14 0.02 −0.28 0.02 0.59
Sex (Male = 1) −10.10+ −3.68 −9.91 0.62+ −66.51 0.48 1.97
Caucasian 1.28 −8.74 1.12 0.59 −55.16 1.3 −70.26*
Black −6.04 −20.99+ −24.41 0.41 −126.35 1.34 −96.78**
Asian −24.33 −13.21 −12.35 0.27 51.49 1.11 −51.81
BMI 0.45 0.24 −0.05 −0.04 14.17** −0.06+ 4.17**
HGB 0.19 0.05 −0.32 n/a n/a n/a n/a
Platelets 0.19** 0.25** n/a n/a n/a n/a n/a
Urea 1.07** 1.29** 1.28** n/a n/a n/a n/a
eGFR 0.03 0.31* 0.59** −0.02** 0.57 −0.01* −0.34
Aspirin (1 = Yes) −57.18** n/a n/a n/a n/a n/a n/a
Clopidogrel (1 = Yes) n/a −32.64** n/a n/a n/a n/a n/a
Diabetes (1 = Yes) n/a n/a n/a n/a n/a n/a −21.04
Intercept −6.29** −42.76** 99.29** 7.58** 771.61** 10.69** 151.92**
Adjusted R 2 0.54 0.39 0.11 0.12 0.07 0.04 0.11
Significance 0 0 0.006 0.002 0.025 0.11 0.004

Abbreviations: ADP, adenosine diphosphate; ASPI, aspirin; BMI, body mass index; eGFR, estimated glomerular filtration rate; ETP, endogenous thrombin potential; HGB, hemoglobin; TRAP, thrombin receptor activating peptide.

Notes: Significance level: ** P ≤ .01; * P ≤ .05; + P ≤ .10. Time to peak was not included as regression model was not statistically significant.