TABLE 5.
Multiple electrode aggregometry | Thrombin generation assays | ||||||
---|---|---|---|---|---|---|---|
ASPI test | ADP test | TRAP test | Lag Time | ETP | Time to peak | Peak thrombin | |
Age | −0.16 | 0.12 | 0.14 | 0.02 | −0.28 | 0.02 | 0.59 |
Sex (Male = 1) | −10.10+ | −3.68 | −9.91 | 0.62+ | −66.51 | 0.48 | 1.97 |
Caucasian | 1.28 | −8.74 | 1.12 | 0.59 | −55.16 | 1.3 | −70.26* |
Black | −6.04 | −20.99+ | −24.41 | 0.41 | −126.35 | 1.34 | −96.78** |
Asian | −24.33 | −13.21 | −12.35 | 0.27 | 51.49 | 1.11 | −51.81 |
BMI | 0.45 | 0.24 | −0.05 | −0.04 | 14.17** | −0.06+ | 4.17** |
HGB | 0.19 | 0.05 | −0.32 | n/a | n/a | n/a | n/a |
Platelets | 0.19** | 0.25** | n/a | n/a | n/a | n/a | n/a |
Urea | 1.07** | 1.29** | 1.28** | n/a | n/a | n/a | n/a |
eGFR | 0.03 | 0.31* | 0.59** | −0.02** | 0.57 | −0.01* | −0.34 |
Aspirin (1 = Yes) | −57.18** | n/a | n/a | n/a | n/a | n/a | n/a |
Clopidogrel (1 = Yes) | n/a | −32.64** | n/a | n/a | n/a | n/a | n/a |
Diabetes (1 = Yes) | n/a | n/a | n/a | n/a | n/a | n/a | −21.04 |
Intercept | −6.29** | −42.76** | 99.29** | 7.58** | 771.61** | 10.69** | 151.92** |
Adjusted R 2 | 0.54 | 0.39 | 0.11 | 0.12 | 0.07 | 0.04 | 0.11 |
Significance | 0 | 0 | 0.006 | 0.002 | 0.025 | 0.11 | 0.004 |
Abbreviations: ADP, adenosine diphosphate; ASPI, aspirin; BMI, body mass index; eGFR, estimated glomerular filtration rate; ETP, endogenous thrombin potential; HGB, hemoglobin; TRAP, thrombin receptor activating peptide.
Notes: Significance level: ** P ≤ .01; * P ≤ .05; + P ≤ .10. Time to peak was not included as regression model was not statistically significant.