FIGURE 2.

PD1_n‐3DPA incubation increases the frequency and amplitude of IPSCs recorded in CA1 pyramidal neurons. (A) sIPSC interevent interval (IEI) presented as cumulative probability curves (Kolmogorov‐Smirnov test D = .098, p < .01) and cell‐based averages (insert) of sIPSC frequency. (B) mIPSCs, same presentation as (A), IEI (Kolmogorov‐Smirnov test D = .102, p < .01) and average frequencies. (C and D) sIPSC and mIPSC amplitudes, respectively, presented as cumulative probability curves (Kolmogorov‐Smirnov test sIPSCS: D = .272, p < .01; mIPSCs: D = .181, p < .01) and cell‐based averages (insert). (E and F) Rise‐times of sIPSCs and mIPSCs, respectively, presented as cumulative probability curves (Kolmogorov‐Smirnov test sIPSCS: D = .029, p > .01; mIPSCs: D = .101, p < .01) and cell‐based averages (inserts). Arrows denote 2 distinct distribution peaks around 1 and 3 ms. Insets display the median and range of cell averages. * Mann‐Whitney p < .05 for cell averages. (G) representative traces of sIPSCs with and without PD1_n‐3DPA. Highlighted segment (green) shows 10‐fold time‐stretched recording. (H) magnification of amplitude‐normalized averaged fast (black) and slow (grey) rise‐time events in cells from control slices (n = 125 sIPSCs per group)