TABLE 1.
Case presentation
| Characteristics | Pre‐transfusion 10:00 AM | Post‐transfusion 2:00 PM |
|---|---|---|
| Initial symptom | Increased respiratory rate and hypoxemia | |
| Time to onset of symptoms | 2 h | |
| Respiratory rate (breaths/min) | 12 | 32 |
| Oxygen saturation | 98% | 75% |
| PaO2 (kPa) | — | 7.1 |
| Supplemental O2 | No | NIV – FiO2 80% |
| Mechanical ventilation required | No | Yes |
| PaO2/FiO2‐ratio | — | 67 |
| Heart rate (beats/min): | 78 | 150 |
| Blood pressure (mmHg) | 97/88 | 80/47 |
| Vasopressors | No | Yes |
| Temperature (°C) | 37.2 | 37.0 |
| Lung auscultation | Clear breath sounds | Decreased basal breath sounds bilaterally |
| Leucocytes (×109) | 16.2 | 1.4 |
| Chest X‐ray | — | Perihilar alveolar edema & spotty consolidations |
| Severity | Grade 3 a | |
| ICU length of stay | 4 days | |
| Duration of mechanical ventilation | 24 h | |
Abbreviations: NIV, Non‐invasive ventilation; FiO2, Fraction of inspired oxygen; ICU, Intensive care unit.
a
Severity grade according to TRIP and ISBT‐IHN definitions, see https://www.isbtweb.org/fileadmin/user_upload/Proposed_definitions_2011_surveillance_non_infectious_adverse_reactions_haemovigilance_incl_TRALI_correction_2013_TACO_correction_2018.pdf.