Figure 1.
Impact of sex and aging on cardiovascular parameters and tissue weights. Main effects from two-way ANOVA are listed in the legend and results of Sidak’s multiple comparison tests are indicated on each graph. n = 8–11 mice/group. A: systolic blood pressure (BP) measured by tail cuff was higher blood in male adults but not in middle-aged male mice. Pint = 0.002, Page = 0.44, Psex = 0.79. B: similarly, PWV was higher in adult male mice but not in middle-aged mice. Pint = 0.14, Page < 0.0001, Psex = 0.0002. C: total body weight was significantly greater in male adults and was increased by age in male but not female mice. Pint = 0.002, Page < 0.0001, Psex < 0.0001. D: tibia length was not impacted by sex or age. Pint = 0.94, Page = 0.0009, Psex = 0.36. E: heart weight normalized to tibia length was increased by aging only in male mice, resulting in a sex difference in middle age. Pint = 0.001, Page = 0.50, Psex = 0.004. F: normalized kidney weights were significantly higher in male mice of both age groups. Pint = 0.0001, Page = 0.0002, Psex < 0.0001. PWV, pulse wave velocity.