Figure 3.

Impact of sex and aging on mesenteric artery reactivity. Main effects from two-way ANOVA are listed on each graph and asterisks denote results of post hoc tests. n = 7–10 mice/group. A and B: no sex effect was detected in the PE response in adulthood (A), but middle-aged females had a significantly enhanced response (B). C and D: response to PGF2α was attenuated in female adults (C), but this pattern was switched in middle age (D). E and F: male mice had significantly blunted ACh-induced relaxation in adulthood (E), which was maintained in middle age (F). G and H: SNP-induced relaxation was not different by sex in adulthood (G) but was attenuated in middle-aged males (H). PE, phenylephrine; PWV, pulse wave velocity; SNP, sodium nitroprusside.