Figure 6.

Impact of sex and aging on mesenteric artery reactivity in global GPER knockout mice. Main effects from two-way ANOVA are listed on each graph. Post hoc tests did not reach statistical significance. n = 6 to 7 mice/group. A and B: no sex effect was detected in the PE response in either adulthood (A) or middle age (B). C and D: response to PGF2α was attenuated in female adults (C), but this pattern was switched in middle age (D). E and F: male mice have significantly blunted ACh-induced relaxation in adulthood (E), which was maintained in middle age (F). G and H: SNP-induced relaxation was not different by sex in adulthood (G) but was attenuated in middle-aged males (H). PE, phenylephrine; SNP, sodium nitroprusside.