TABLE 2.
Prediction models using 10 different variable sets
| Variable set | Variables | Accuracy (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|---|
| 1 | Top 10 LASSO‐selected miRNAs | hsa‐miR‐382‐5p, hsa‐miR‐193a‐5p, hsa‐miR‐501‐3p, hsa‐miR‐21‐5p, hsa‐miR‐877‐5p, hsa‐miR‐141‐3p, hsa‐miR‐375, hsa‐miR‐32‐5p, hsa‐miR‐2110, hsa‐miR‐1260a | 1 (0.91‐1) | 1 (0.74‐1) | 1 (0.87‐1) |
| 2 | Top 15 LASSO‐selected miRNAs | hsa‐miR‐382‐5p, hsa‐miR‐193a‐5p, hsa‐miR‐501‐3p, hsa‐miR‐21‐5p, hsa‐miR‐877‐5p, hsa‐miR‐141‐3p, hsa‐miR‐375, hsa‐miR‐32‐5p, hsa‐miR‐2110, hsa‐miR‐1260a, hsa‐miR‐140‐5p, hsa‐miR‐543, hsa‐miR‐26a‐5p, hsa‐miR‐27b‐3p, hsa‐miR‐423‐3p | 1 (0.91‐1) | 1 (0.74‐1) | 1 (0.87‐1) |
| 3 | Top 20 LASSO‐selected miRNAs | hsa‐miR‐382‐5p, hsa‐miR‐193a‐5p, hsa‐miR‐501‐3p, hsa‐miR‐21‐5p, hsa‐miR‐877‐5p, hsa‐miR‐141‐3p, hsa‐miR‐375, hsa‐miR‐32‐5p, hsa‐miR‐2110, hsa‐miR‐1260a, hsa‐miR‐140‐5p, hsa‐miR‐543, hsa‐miR‐26a‐5p, hsa‐miR‐27b‐3p, hsa‐miR‐423‐3p, hsa‐miR‐151a‐5p, hsa‐miR‐29b‐3p, hsa‐miR‐1‐3p, hsa‐miR‐30e‐5p, hsa‐miR‐125a‐5p | 0.974 (0.86‐1) | 0.917 (0.62‐1) | 1 (0.87‐1) |
| 4 | 8 LASSO‐selected miRNAs and clinical variables | T2D medication, age, hsa‐miR‐382‐5p, hsa‐miR‐32‐5p, fasting blood glucose, sex, hsa‐miR‐1‐3p, hsa‐miR‐21‐5p | 0.974 (0.86‐1) | 0.917 (0.62‐1) | 1 (0.87‐1) |
| 5 | All clinical variables | All clinical variables (26) | 0.947 (0.82‐0.99) | 0.833 (0.52‐0.98) | 1 (0.87‐1) |
| 6 | 4 LASSO‐selected clinical variables | T2D medication, age, fasting blood glucose, sex | 0.947 (0.82‐0.99) | 0.833 (0.52‐0.98) | 1 (0.87‐1) |
| 7 | All available variables | All miRNAs and clinical variables (205) | 0.947 (0.82‐0.99) | 0.833 (0.52‐0.98) | 1 (0.87‐1) |
| 8 | Top 5 LASSO‐selected miRNAs | hsa‐miR‐382‐5p, hsa‐miR‐193a‐5p, hsa‐miR‐501‐3p, hsa‐miR‐21‐5p, hsa‐miR‐877‐5p | 0.921 (0.79‐0.98) | 0.917 (0.62‐1) | 0.923 (0.75‐0.99) |
| 9 | All miRNAs | All miRNAs (179) | 0.842 (0.69‐0.94) | 0.583 (0.28‐0.85) | 0.962 (0.8‐1) |
| 10 | GeneGlobe miRNAs | hsa‐miR‐409‐3p, hsa‐miR‐382‐5p, hsa‐miR‐375, hsa‐miR‐1‐3p | 0.789 (0.63‐0.9) | 0.5 (0.21‐0.79) | 0.923 (0.75‐0.99) |
Note: LASSO models ranked based on accuracy. Abbreviations: LASSO, Least Absolute Shrinkage and Selection Operator; miRNA, microRNA; T2D, type 2 diabetes.