TABLE 5.
Obesity‐ and insulin resistance‐related pathways regulated by the four predictive miRNAs
| No. | KEGG pathway | p value | No. of genes | No. of miRNAs |
|---|---|---|---|---|
| 1 | Thyroid hormone signaling pathway | 9.22E‐05 | 33 | 3 |
| 2 | Lysine degradation | 2.04E‐04 | 15 | 2 |
| 3 | FoxO signaling pathway | 2.34E‐04 | 41 | 3 |
| 4 | Fatty acid elongation | 0.0012 | 7 | 3 |
| 5 | Prolactin signaling pathway | 0.0014 | 21 | 3 |
| 6 | Focal adhesion | 0.0021 | 52 | 3 |
| 7 | Adherens junction | 0.0024 | 20 | 2 |
| 8 | ECM‐receptor interaction | 0.0025 | 19 | 3 |
| 9 | Valine, leucine, and isoleucine biosynthesis | 0.0036 | 2 | 2 |
| 10 | Regulation of actin cytoskeleton | 0.0061 | 50 | 3 |
| 11 | MAPK signaling pathway | 0.0102 | 54 | 3 |
| 12 | p53 signaling pathway | 0.0102 | 21 | 3 |
| 13 | mTOR signaling pathway | 0.0133 | 18 | 3 |
| 14 | Protein processing in endoplasmic reticulum | 0.0140 | 39 | 3 |
| 15 | Hippo signaling pathway | 0.0157 | 32 | 3 |
| 16 | Fatty acid degradation | 0.0241 | 7 | 2 |
| 17 | Endocytosis | 0.0263 | 41 | 3 |
| 18 | PI3K‐Akt signaling pathway | 0.0370 | 68 | 3 |
| 19 | HIF‐1 signaling pathway | 0.0478 | 26 | 3 |
Abbreviations: ECM, extracellular matrix; FoxO, forkhead box protein O; HIF‐1, hypoxia‐inducible factor 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen‐activated protein kinase; miRNA, microRNA; mTOR, mechanistic target of rapamycin (serine/threonine kinase); PI3K‐Akt, phosphatidylinositol 3‐kinase‐protein kinase b.