TABLE 1.
Overview of variables
| Description | Nature |
|---|---|
| HRCT pattern (UIP‐like fibrotic pattern; other fibrotic patterns) a | Baseline |
| Relative decline in DLCO b >15% predicted within 12 months | Time‐varying |
| Relative decline in FVC >10% predicted with 12 months | Time‐varying |
| Relative decline in weight >5% within 12 months | Time‐varying |
| Age (years) | Baseline |
| Sex | Baseline |
| Treatment (nintedanib; placebo) | Baseline |
| FVC, ml | Baseline |
| FVC % predicted | Baseline |
| DLCO % predicted b | Baseline |
| Race (Asian; Black/African American; White) | Baseline |
| BMI (kg/m2) | Baseline |
| Tobacco consumption (current and former; never) | Baseline |
| Time since diagnosis (years) | Baseline |
| ILD diagnosis (iNSIP, unclassifiable IIP, HP, autoimmune ILDs, other ILDs) a | Baseline |
a
INBUILD trial only.
b
Corrected for haemoglobin.
Abbreviations: DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; HP, hypersensitivity pneumonitis; IIP, idiopathic interstitial pneumonia; ILD, interstitial lung disease; iNSIP, idiopathic non‐specific interstitial pneumonia; UIP, usual interstitial pneumonia.