Table 2.
In silico toxicology of NZ and NZ-NO using ADMET Predictor™.
| Parameter | NZ | NZ-NO |
|---|---|---|
| Rat_TD50 (mg/kg) | 12.857 | 0.966 |
| Mouse_TD50 (mg/kg) | 20.747 | 2.207 |
| TOX_FHM (mg/L) | 0.275 | 0.162 |
| Rat-acute LD50 (mg/kg) | 1382.32 | 1091.22 |
| Chrom_Aberr | Non-toxic | Toxic |
| Ser_AST | Normal | Elevated |
| Ser_ALT | Normal | Normal |
| MUT_Riska | 0.5 | 3 |
| TOX_Riskb | 0.95 | 3 |
Rat_TD50: median toxic dose in rat, Mouse_TD50: median toxic dose in mouse, TOX_FHM: fathead minnow model, Rat-acute LD50: median lethal dose rat acute toxicity, Ser_AST: serum aspartate aminotransferase, Ser_ALT: serum alanine aminotransferase, MUT_Risk: overall mutagenicity, and TOX_Risk: overall toxicity.
a
Desired value is <1.
b
Desired value is <3.