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. 2022 Feb 17;70(6):1117–1132. doi: 10.1002/glia.24160

FIGURE 1.

FIGURE 1

Decreased tau pathology in NLRP3‐deficient tau mice. Representative images of AT8 (anti‐tau P‐S202/T205) (a) and AT100 (anti‐tau P‐T212/S214) (b) immunostaining of the hippocampal CA1 region of tau.NLRP3−/− (T+.N−/−, lower panels) and tau.NLRP3+/+ (T+.N+/+, upper panels) mice. Higher magnifications of selected areas (white squared boxes) are shown on the right. (c) Quantitative analysis of immunostaining showed significantly decreased levels of tau phosphorylation in the CA1 region of the hippocampus of 10‐month‐old T+.N−/− (lower panels) versus T+.N+/+ (upper panels) mice. (d) Biochemical analysis of tau aggregation, by homogeneous time resolved fluorescence (HTRF) assay (left side), showed significantly decreased levels of tau aggregates in the NLRP3‐deficient tau (T+.N−/−) compared to wild‐type NLRP3 tau (T+.N+/+) mice (right side). Data are shown as mean ± SEM (T+.N+/+: N = 7; T+.N−/−: n = 6; *p < .05, **p < .01; unpaired Welch's t‐test; AT8, bar = 250 μm; AT100, bar = 100 μm)