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. 2022 Feb 17;70(6):1117–1132. doi: 10.1002/glia.24160

FIGURE 4.

FIGURE 4

Decreased tau pathology in frontal cortex of tau‐seeded NLRP3‐deficient tau mice. (a) Representative images of AT8 (anti‐tau P‐S202/T205, left panels) and AT100 (anti‐tau P‐T212/S214, right panels) immunolabeling of the ipsilateral frontal cortex of tau.NLRP3−/− (T+.N−/−) and tau.NLRP3+/+ (T+.N+/+), showing decreased levels of tau phosphorylation in tau‐seeded T+.N−/− (lower panels) versus tau‐seeded T+.N+/+ (upper panels) mice. (b) Higher magnification of the ipsilateral frontal cortex region (corresponding to the white squared boxes in a) are shown. (c) Quantitative analysis showed significantly decreased AT8‐ and AT100‐positive area in the ipsilateral frontal cortex of tau‐seeded T+.N−/− versus tau‐seeded T+.N+/+ mice. Data are shown as mean ± SEM (T+.N+/+: n = 7; T+.N−/−: n = 9; *p < .05; unpaired Welch's t‐test; AT8, bar = 250 μm; AT100, bar = 100 μm)