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. 2022 Feb 17;70(6):1117–1132. doi: 10.1002/glia.24160

FIGURE 5.

FIGURE 5

Decreased spreading of tau pathology in tau seeded NLRP3‐deficient tau mice. (a) Representative images of AT8 (anti‐tau P‐S202/T205, left panels) and AT100 (anti‐tau P‐T212/S214, right panels) immunolabeling of the contralateral CA1 hippocampal region of tau.NLRP3−/− (T+.N−/−) and tau.NLRP3+/+ (T+.N+/+), showing significantly decreased levels of tau phosphorylation of the tau seeded T+.N−/− (lower panels) versus tau seeded T+.N+/+ (upper panels) mice. (b) Higher magnification of the CA1 region (corresponding to the white squared boxes in a) are shown. (c) Quantitative analysis showed significantly decreased AT8‐ and AT100‐positive area in the contralateral CA1 region of the tau‐seeded T+.N−/− versus tau‐seeded T+.N+/+ mice. Data are shown as mean ± SEM (T+.N+/+: n = 7; T+.N−/−: n = 9; **p < .01, ***p < .001; unpaired Welch's t‐test; bar = 250 μm)